Basic Information
| LncRNA/CircRNA Name | LINC00313 |
| Synonyms | C21orf84, NCRNA00313, CH507-42P11.5 |
| Region | GRCh38_21:43462094-43479534 |
| Ensemble | ENSG00000185186 |
| Refseq | NR_026863 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | PCR, RIP, Western blot analysis etc. |
| Sample | Seventy-four thyroid cancer tissue, The human thyroid cancer cell lines, including TPC-1, K1, SW579, and NPA |
| Expression Pattern | down-regulated |
| Function Description | LINC00313 was overexpressed, whereas ALX4 was downregulated in thyroid cancer, the results of which were also verified in thyroid cancer tissues. Besides, our results demonstrated that LINC00313 bound to the ALX4 promoter region, and LINC00313 recruited DNMT1 and DNMT3B proteins to promote the methylation of ALX4 promoter region, thus suppressing the ALX4 expression. Finally, the downregulation of LINC00313 and upregulation of ALX4 repressed the AKT/mTOR signaling axis, thus inhibiting proliferative, migratory, invasive abilities as well as epithelial-to-mesenchymal transition (EMT) of thyroid cancer cells. |
| Pubmed ID | 31093972 |
| Year | 2019 |
| Title | Downregulated long noncoding RNA LINC00313 inhibits the epithelial-mesenchymal transition, invasion, andmigration of thyroid cancer cells through inhibiting the methylation of ALX4 |
External Links
| Links for LINC00313 | GenBank HGNC NONCODE |
| Links for thyroid cancer | OMIM COSMIC |