Basic Information
| LncRNA/CircRNA Name | LINC00312 |
| Synonyms | NA |
| Region | GRCh38_1:29554-31109 |
| Ensemble | |
| Refseq | NR_024065 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, luciferase reporter assay |
| Sample | colorectal cancer tissues, cell lines (SW480, SW620, LoVo, HT29, NCM460) |
| Expression Pattern | down-regulated |
| Function Description | LINC00312 is underexpressed in CRC tissues and cell lines. LINC00312 suppresses growth, migration and invasion of CRC cells in vitro and attenuates tumour proliferation and metastasis in vivo. LINC00312 was found to regulate the malignancy of CRC cells by binding to miR-21 and by functioning as a tumour suppressor targeting PTEN. |
| Pubmed ID | 30134003 |
| Year | 2018 |
| Title | LINC00312 represses proliferation and metastasis of colorectal cancer cells by regulation of miR-21. |
External Links
| Links for LINC00312 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |