Basic Information
| LncRNA/CircRNA Name | LINC00312 |
| Synonyms | NA |
| Region | GRCh38_1:29554-31109 |
| Ensemble | |
| Refseq | NR_024065 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot |
| Sample | ovarian cancer tissues, cell lines (SKOV3 and SKOV3/DDP) |
| Expression Pattern | down-regulated |
| Function Description | The expression of Linc00312 decreased significantly in SKOV3/DDP cells compared to that in SKOV3 cells. Linc00312 inhibited cell proliferation and promoted cell apoptosis in SKOV3 and SKOV3/DDP cells. Upregulation of Linc00312 can considerably increase the sensitivity of SKOV3/DDP cells to cisplatin, while down-regulation of Linc00312 has the exact opposite effect in SKOV3 cells. Linc00312 enhanced the sensitivity of SKOV3/DDP cells to cisplatin by promoting cell apoptosis via the Bcl-2/Caspase-3 signaling pathway. |
| Pubmed ID | 29952351 |
| Year | 2018 |
| Title | Long Non-Coding RNA Linc00312 Modulates the Sensitivity of Ovarian Cancer to Cisplatin via the Bcl-2/Caspase-3 Signaling Pathway |
External Links
| Links for LINC00312 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |