Basic Information
| LncRNA/CircRNA Name | LINC00311 |
| Synonyms | NA |
| Region | GRCh38_16:85282958-85285963 |
| Ensemble | ENSG00000179219 |
| Refseq | XR_017879 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot assay, Dual luciferase reporter assay, RIP |
| Sample | tumor and adjacent nontumor tissues,thyroid cell line (HTori-3), PTC cell lines (KTC-1, K1, SNU-790, TPC-1), and HEK293 cells |
| Expression Pattern | up-regulated |
| Function Description | the expression of LINC00311 was upregulated in PTC tissues and cells. Furthermore, knockdown of LINC00311 dramatically suppressed spheroid formation, proliferation, migration, and invasion in PTC cells in vitro. Mechanistic investigations revealed that LINC00311 was negatively correlated with the expression of miR-330-5p, meanwhile, TLR4 was a direct target of miR-330-5p. In addition, rescue assays further determined that LINC00311 contributed to the progression of PTC through regulating TLR4 expression. |
| Pubmed ID | 31894666 |
| Year | 2020 |
| Title | LINC00311 Promotes Cancer Stem-Like Properties by Targeting miR-330-5p/TLR4 Pathway in Human Papillary Thyroid Cancer |
External Links
| Links for LINC00311 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |