Basic Information
| LncRNA/CircRNA Name | LINC00310 |
| Synonyms | C21orf82, NCRNA00310 |
| Region | GRCh38_21:34157724-34190244 |
| Ensemble | ENSG00000227456 |
| Refseq | NR_027266 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR, Western blot analysis |
| Sample | Human cell lines (MCF-7, MDA-MB-231, HMLE and HEK-293T), LM-4142 cells, breast cancer cell lines (MCF-7, MDA-MB-231 and LM-4142), breast cancer tissue and the normal tissues |
| Expression Pattern | up-regulated |
| Function Description | LINC00310 was increased as breast cancer progressed, and the deregulation of LINC00310 was significantly associated with patients' survival. LINC00310 promoted cell proliferation by regulating c-Myc expression in?vitro. LINC00310 KO significantly suppressed tumour growth in?vivo. serum LINC00310 expression was significantly up-regulated in patients with breast cancer, LINC00310 had a powerful capability of distinguishing patients with breast cancer from healthy individuals |
| Pubmed ID | 29993199 |
| Year | 2018 |
| Title | The oncogenic potentials and diagnostic significance of long non-coding RNALINC00310 in breast cancer. |
External Links
| Links for LINC00310 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |