Basic Information
| LncRNA/CircRNA Name | LINC00310 |
| Synonyms | NA |
| Region | GRCh38_21:34157724-34190244 |
| Ensemble | ENSG00000227456 |
| Refseq | NR_027266 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot |
| Sample | breast cancer serum, cell lines(MCF-7, MDA-MB-231, HMLE and HEK-293T) |
| Expression Pattern | up-regulated |
| Function Description | Experiments with knockout (KO) approach by CRISPR/Cas9 system and the subsequent rescue experiments revealed that LINC00310 promoted cell proliferation by regulating c-Myc expression in vitro. Nude mouse xenograft assay demonstrated that LINC00310 KO significantly suppressed tumour growth in vivo. Furthermore, we found that serum LINC00310 expression was significantly up-regulated in patients with breast cancer, and receiver operating characteristic (ROC) curve analysis indicated that LINC00310 had a powerful capability of distinguishing patients with breast cancer from healthy individuals (the area under curve 0.828). |
| Pubmed ID | 29993199 |
| Year | 2018 |
| Title | The Oncogenic Potentials and Diagnostic Significance of Long Non-Coding RNA LINC00310 in Breast Cancer |
External Links
| Links for LINC00310 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |