Basic Information
| LncRNA/CircRNA Name | LINC00304 |
| Synonyms | NA |
| Region | GRCh38_16:89159146-89164245 |
| Ensemble | ENSG00000180422 |
| Refseq | NR_024347 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qRT-PCR , RNAi etc. |
| Sample | PCa and normal prostate tissues,cell lines(LNCaP cells, 22RV1, DU145, PC-3, and WPMY-1) |
| Expression Pattern | up-regulated |
| Function Description | We observed higher expression of LINC00304 in PCa cells and samples compared with normal prostate cells and tissues.Functional analysis of LINC00304 showed it was related to regulating cell cycle process, cellular developmental process, and focal adhesion.Further, we identified androgen-inhibited lncRNA, LINC00304 as a direct target of AR. overexpression of LINC00304 could significantly promote cell proliferation and cell cycle progression in PCa cells. We also find that LINC00304 can significantly promote CCNA1 expression in PCa cells.LINC00304 promoted PCa cell proliferation and cell cycle, and inhibited apoptosis in PCa cells by promoting CCNA1 expression. |
| Pubmed ID | 31012142 |
| Year | 2019 |
| Title | Androgen-responsive lncRNA LINC00304 Promotes Cell Cycle and Proliferation via Regulating CCNA1 |
External Links
| Links for LINC00304 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |