Basic Information
| LncRNA/CircRNA Name | LINC00273 |
| Synonyms | NA |
| Region | GRCh38_16:34158585-34160036 |
| Ensemble | ENSG00000256642 |
| Refseq | NR_038368 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR, Western blot |
| Sample | lung cancer tissue,cell lines |
| Expression Pattern | up-regulated |
| Function Description | LINC00273 promoted TGF?-induced lung cancer EMT through miR-200a-3p/ZEB1 feedback loop and may serve as a potential target for therapeutic intervention in lung cancer metastasis. |
| Pubmed ID | 32017082 |
| Year | 2020 |
| Title | TGF? mediated LINC00273 upregulation sponges mir200a-3p and promotes invasion and metastasis by activating ZEB1 |
External Links
| Links for LINC00273 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |