Basic Information
| LncRNA/CircRNA Name | LINC00261 |
| Synonyms | LINC00261, ALIEN, C20orf56, DEANR1, HCCDR1, NCRNA00261, onco-lncRNA-17 |
| Region | GRCh38_20:22547671-22578642 |
| Ensemble | ENSG00000259974 |
| Refseq | NR_001558 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot etc. |
| Sample | gastric cancer tissues, cell lines (MGC-803, SGC-7901, AGS) |
| Expression Pattern | down-regulated |
| Function Description | In this study, we report that linc00261 was significantly down-regulated in GC tissues and the expression level of linc00261 negatively correlated with advanced tumour status and clinical stage as well as poor prognostic outcome. In vitro functional assays indicate that ectopic expression of linc00261 suppressed cell invasion by inhibiting the epithelial-mesenchymal transition (EMT). By RNA pull-down and mass spectrum experiments, we identified Slug as an RNA-binding protein that binds to linc00261. We confirmed that linc00261 down-regulated Slug by decreasing the stability of Slug proteins and that the tumour-suppressive function of linc00261 can be neutralized by Slug. linc00261 may promote the degradation of Slug via enhancing the interaction between GSK3B and Slug. |
| Pubmed ID | 27878953 |
| Year | 2016 |
| Title | Long non-coding RNA linc00261 suppresses gastric cancer progression via promoting Slug degradation. |
External Links
| Links for LINC00261 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |