Basic Information
| LncRNA/CircRNA Name | LINC00261 |
| Synonyms | NA |
| Region | GRCh38_20:22547671-22578642 |
| Ensemble | ENSG00000259974 |
| Refseq | NR_001558 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , Western blot , RIP , in vitro knockdown etc. |
| Sample | NSCLC tissues and adjacent normal tissues ,NSCLC cell line (A549, H1650, PC-9,SPCA1) and the normal lung bronchial epithelial cell line BEAS-2B |
| Expression Pattern | down-regulated |
| Function Description | Linc00261 expressed significantly lower in NSCLC tissues and cell lines than that in the adjacent normal tissues or control cell line.Over-expression of linc00261 significantly inhibited proliferation, invasion and migration of NSCLC cells.On the contrast, knockdown of linc00261 promoted cell growth and metastasis of NSCLC cells. Furthermore, linc00261 inhibited the epithelial-mesenchymal transition of NSCLC via downregulating Snail. Linc00261 could slow down the growth of xenograft of NSCLC in vivo.linc00261 was lowly expressed in NSCLC tissues and cells. It inhibited cell proliferation and metastasis by downregulating Snail expression via EMT. |
| Pubmed ID | 31115010 |
| Year | 2019 |
| Title | Linc00261 Suppresses Growth and Metastasis of Non-Small Cell Lung Cancer via Repressing Epithelial-Mesenchymal Transition |
External Links
| Links for LINC00261 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |