Basic Information
| LncRNA/CircRNA Name | LINC00261 |
| Synonyms | NA |
| Region | GRCh38_20:22547671-22578642 |
| Ensemble | ENSG00000259974 |
| Refseq | NR_001558 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qRT-PCR , Western blot , RIP etc. |
| Sample | colon cancer tissues ,Human colon cancer cells lines( HCT-116, DLD-1, SW620, HT-29,SW480 cells), normal human colonic epithelial cells HCEpic |
| Expression Pattern | up-regulated |
| Function Description | LINC00261 was reduced in colon cancer cells. Meanwhile, overexpressed LINC00261 repressed colon cancer cell viability and proliferation capacity. In addition, colony cancer cell colony formation was inhibited and apoptosis was enhanced by upregulation of LINC00261.Also, colon cancer cell migration and invasion both were restrained by LINC00261.Overexpression of LINC00261 obviously impaired colon cancer progression via inactivating the Wnt pathway. Furthermore, an increase of LINC00261 could suppress colon tumor growth via sponging miR-324-3p and inactivating the Wnt pathway. |
| Pubmed ID | 31183860 |
| Year | 2019 |
| Title | LINC00261 Suppresses Human Colon Cancer Progression via Sponging miR-324-3p and Inactivating the Wnt/?-catenin Pathway |
External Links
| Links for LINC00261 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |