Basic Information
| LncRNA/CircRNA Name | LINC00261 |
| Synonyms | NA |
| Region | GRCh38_20:22547671-22578642 |
| Ensemble | ENSG00000259974 |
| Refseq | NR_001558 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cholangiocarcinoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, western blot assay |
| Sample | cancerous tissues,QBC939 and RBE cells,cell line, HIBEC, and CCA cells, including Huh-28, HuCCT1 and CCLP-1 |
| Expression Pattern | up-regulated |
| Function Description | LINC00261 was overexpressed in cancerous tissues and CCA cell lines compared with adjacent tissues and HIBEC.LINC00261 an independent prognostic factor in CCA patients.Knockdown of LINC00261 expression in RBE and QBC939 cell lines inhibited cell proliferation, migration and invasion property and increased cell apoptosis and the EMT progression. |
| Pubmed ID | 31812439 |
| Year | 2020 |
| Title | Up-regulated LINC00261 Predicts a Poor Prognosis and Promotes a Metastasis by EMT Process in Cholangiocarcinoma |
External Links
| Links for LINC00261 | GenBank HGNC NONCODE |
| Links for cholangiocarcinoma | OMIM COSMIC |