Basic Information
| LncRNA/CircRNA Name | LINC00222 |
| Synonyms | C6orf181, dJ354J5.2, NCRNA00222 |
| Region | GRCh38_6:108751654-108769942 |
| Ensemble | ENSG00000203801 |
| Refseq | NR_033376 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | PCR, Western blot analysis |
| Sample | The human lung adenocarcinoma cell lines (SPC-A-1 and LTEP-a-2), lung adenocarcinoma tissues and adjacent non-tumor lung tissues |
| Expression Pattern | down-regulated |
| Function Description | LINC00222 is downregulated in lung adenocarcinoma tissues. Enforced expression of LINC00222 significantly inhibited the proliferation, migration and invasive ability of lung adenocarcinoma cells, and also induced apoptosis. Furthermore, overexpression of LINC00222 enhanced the activity of glycogen synthase kinase-3B (GSK3B), which is a key element of the Wnt signaling pathway. |
| Pubmed ID | 29990868 |
| Year | 2018 |
| Title | Long non-coding RNA LINC00222 regulates GSK3? activity and promotes cell apoptosis in lung adenocarcinoma. |
External Links
| Links for LINC00222 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |