Basic Information
| LncRNA/CircRNA Name | LINC00221 |
| Synonyms | NA |
| Region | GRCh38_14:106482439-106521073 |
| Ensemble | ENSG00000270816 |
| Refseq | NR_027457 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute lymphoblastic leukemia |
| ICD-0-3 | NA |
| Methods | qPCR, Luciferase reporter assay, RNAi, RIP etc. |
| Sample | AML tissues,cell lines (Jurkat, CCRF-CEM, CEM/C1, 1301, HEK 293T) |
| Expression Pattern | down-regulated |
| Function Description | Our study revealed the low expression of LINC00221 in ALL cells. Subsequently, LINC00221 was verified to bind with miR-152-3p. Moreover, functional assays pointed out that LINC00221 overexpression posed anti-proliferation and pro-apoptosis effects in ALL cells, and these effects could be separately reversed by miR-152-3p up-regulation. Afterward, LINC00221 was revealed to regulate ATP2A2 expression via sponging miR-152-3p. Additionally, ATP2A2 was verified to involve in regulating LINC00221-mediated ALL cell proliferation and apoptosis. In conclusion, LINC00221 suppressed ALL cell proliferation and boosted ALL cell apoptosis via sponging miR-152-3p to up-regulate ATP2A2. |
| Pubmed ID | 32297639 |
| Year | 2020 |
| Title | LINC00221 suppresses the malignancy of children acute lymphoblastic leukemia |
External Links
| Links for LINC00221 | GenBank HGNC NONCODE |
| Links for acute lymphoblastic leukemia | OMIM COSMIC |