Basic Information
| LncRNA/CircRNA Name | LINC00210 |
| Synonyms | LINC00210, NCRNA00210 |
| Region | GRCh38_1:217892900-217920804 |
| Ensemble | ENSG00000231814 |
| Refseq | NR_048550 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | Microarray, qPCR, RIP, in vitro knockdown |
| Sample | cell lines (Hep3B (ATCC HB-8064),PLC (ATCC CRL-8024),293 T (ATCC CRL-3216)), liver cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | Linc00210 promoted self-renewal and tumor initiating capacity of liver TICs through Wnt/B-catenin signaling. Linc00210 interacted with CTNNBIP1 and blocked its inhibitory role in Wnt/B-catenin activation. Linc00210 silencing cells showed enhanced interaction of B-catenin and CTNNBIP1, and impaired interaction of B-catenin and TCF/LEF components.Linc00210 interacts with CTNNBIP1 and blocks the combination between CTNNBIP1 and B-catenin, driving the activation of Wnt/B-catenin signaling. Linc00210-CTNNBIP1-Wnt/B-catenin axis can be targeted for liver TIC elimination. |
| Pubmed ID | 29540185 |
| Year | 2018 |
| Title | Linc00210 drives Wnt/B-catenin signaling activation and liver tumor progression through CTNNBIP1-dependent manner. |
External Links
| Links for LINC00210 | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |