Basic Information
| LncRNA/CircRNA Name | LINC00210 |
| Synonyms | CYTOR, C2orf59, LINC00152, NCRNA00152 |
| Region | GRCh38_1:217892900-217920804 |
| Ensemble | ENSG00000231814 |
| Refseq | NR_048550 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, RNAi, Luciferase reporter assay, RNAi, other |
| Sample | NPC tissues and cell lines (5-8F, 6-10B, S18 and S26) |
| Expression Pattern | up-regulated |
| Function Description | Besides, its overexpression was positively correlated with NPC metastasis while predicting poor prognosis. Based on functional experiments, we revealed that LINC00210 contributed to NPC cell proliferation and invasion in vitro, and promotes tumor growth in vivo Mechanistically, we identified that LINC00210 was located in the cytoplasm of NPC cells and served as the miR-328-5p sponge. Furthermore, we showed that miR-328-5p targets the 3' untranslated region (3'-UTR) of NOTCH3. Through inhibiting miR-328-5p activity, LINC00210 promoted NOTCH3 expression in NPC, leading to activation of NOTCH3 signaling pathway. |
| Pubmed ID | 30341249 |
| Year | 2018 |
| Title | LINC00210 as a miR-328-5p Sponge Promotes Nasopharyngeal Carcinoma Tumorigenesis by Activating NOTCH3 Pathway |
External Links
| Links for LINC00210 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |