Basic Information
| LncRNA/CircRNA Name | LINC00165 |
| Synonyms | C21orf135, NCRNA00165, NLC1-B, NLC1B |
| Region | GRCh38_21:44994362-44995185 |
| Ensemble | ENSG00000261706 |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Luciferase reporter assay, RIP, other |
| Sample | GC tissues and cell line GES-1, human GC cell lines SGC-7901, MGC-803, BGC-823 and AGS |
| Expression Pattern | up-regulated |
| Function Description | Functional assays showed that LINC00165 knockdown inhibited the proliferation, migration and invasion of GC cells and LINC00165 overexpression stimulated their proliferation, migration and invasion.?LINC00165 was involved in the progression and poor prognosis of GC as an oncogenic role. Therefore, LINC00165 might become a new potential target for GC chemotherapy and further predict prognosis of patients. |
| Pubmed ID | 30448060 |
| Year | 2018 |
| Title | Long Noncoding RNA LINC00165-induced by STAT3 Exerts Oncogenic Properties via Interaction With Polycomb Repressive Complex 2 to Promote EMT in Gastric Cancer |
External Links
| Links for LINC00165 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |