Basic Information
| LncRNA/CircRNA Name | LINC00163 |
| Synonyms | NA |
| Region | GRCh38_21:44989864-44994086 |
| Ensemble | ENSG00000234880 |
| Refseq | NR_033840 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, in vitro knockdown, RIP, etc. |
| Sample | lung cancer tissues, Lung cancer cell lines (H1975, SPC-A1, A549, HCC827 and H1299) and the human immortalized normal epithelial cell line (BEAS-2B) |
| Expression Pattern | down-regulated |
| Function Description | LINC00163 level was significantly downregulated in lung cancer tissues and cell lines by bioinformatics and qRT-PCR analyses. Notably, we observed that LINC00163 expression was lower in metastatic tissues than in non-metastatic cases. Furthermore, higher expression of LINC00163 in patients with lung cancer predicted better prognosis. Gain-of-function assays illustrated that upregulation of LINC00163 dramatically suppressed the proliferation, migration and invasion of lung cancer cells in vitro, whereas promoting apoptosis. Consistently, LINC00163 overexpression impaired tumor propagation in vivo. Mechanical study revealed that LINC00163 recruited ARID1A to the promoter of TCF21 and initiated its expression. |
| Pubmed ID | 30662806 |
| Year | 2018 |
| Title | LncRNA LINC00163 upregulation suppresses lung cancer development though transcriptionally increasing TCF21 expression |
External Links
| Links for LINC00163 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |