Basic Information
| LncRNA/CircRNA Name | LINC00161 |
| Synonyms | LINC00161, C21orf100, NCRNA00161 |
| Region | GRCh38_21:28539318-28540355 |
| Ensemble | ENSG00000226935 |
| Refseq | NR_026552 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR, RNAi, RIP, Dual luciferase reporter assay etc. |
| Sample | cell lines (MG-63 and U2OS) |
| Expression Pattern | up-regulated |
| Function Description | Here, we found that lncRNA LINC00161 was induced by cisplatin in osteosarcoma cells. Elevated LINC00161 increased cisplatin-induced apoptosis and reversed the cisplatin-resistant phenotype of osteosarcoma cells by upregulating IFIT2. Further mechanistic studies revealed that LINC00161 could sponge endogenous miR-645 and inhibit its activity leading to IFIT2 increase. In addition, we identified that LINC00161 enhanced cisplatin-induced apoptosis through regulation of the miR-645-IFIT2 pathway. |
| Pubmed ID | 27609068 |
| Year | 2016 |
| Title | Long non-coding RNA LINC00161 sensitises osteosarcoma cells to cisplatin-induced apoptosis by regulating the miR-645-IFIT2 axis. |
External Links
| Links for LINC00161 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |