Basic Information
| LncRNA/CircRNA Name | LINC00161 |
| Synonyms | NA |
| Region | GRCh38_21:28539318-28540355 |
| Ensemble | ENSG00000226935 |
| Refseq | NR_026552 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Cisplatin | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, etc. |
| Sample | ovarian cancer tissues, Human ovarian cancer cell SKOV3, drug-resistant ovarian cancerous cell SKOV3/DDP, CoC1 and CoC1/DDP |
| Expression Pattern | up-regulated |
| Function Description | Linc00161 was highly expressed in ovarian cancer-resistant tissues and SKOV3/DDP cells while the miR-128 displayed a lower expression. Overexpression of linc00161 increased the colony formation ratio in SKOV3 cells, whereas sh-linc00161 reduced colony formation ratio in SKOV3/DDP cells. MAPK1 was highly expressed in ovarian cancer-resistant tissues and cells and could be regulated by linc00161 and miR-128. The proliferation ability of SKOV3 cell was enhanced after transfected with miR-128 inhibitor, whereas that of SKOV3/DDP cells was attenuated by miR-128 mimics. In addition, the colony formation ratio of SKOV3 cells co-transfected with DDP + MAPK1 + sh-linc00161 decreased. The colony formation ratio of SKOV3/DDP cells also declined after transfected with DDP+ MAPK1. Linc00161 regulated the drug resistance of ovarian cancer via modulating microRNA-128/MAPK1. In vivo, sh-linc00161 inhibited the tumor growth. |
| Pubmed ID | 30556928 |
| Year | 2019 |
| Title | Linc00161 regulated the drug resistance of ovarian cancer by sponging microRNA-128 and modulating MAPK1. |
External Links
| Links for LINC00161 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |