Basic Information
| LncRNA/CircRNA Name | LINC00152 |
| Synonyms | CYTOR, C2orf59, LINC00152, NCRNA00152 |
| Region | GRCh38_2:87454781-87636740 |
| Ensemble | ENSG00000222041 |
| Refseq | NR_024204 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Flow cytometry assay, CCK-8 assay etc. |
| Sample | CRC tissues, cell lines (CACO2, HCT-116, HT-29, SW480, and SW620) |
| Expression Pattern | down-regulated |
| Function Description | We found that LINC00152 expression was significantly decreased in CRC tissues and CRC cell lines. Overexpression of LINC00152 resulted in decreased cell viability and increased apoptosis in CSC cell lines. Interestingly, miR-376c-3p down-regulated the expression of LINC00152 in CSC cells. In addition, miR-376c-3p suppressed the effect of LINC00152 on the viability and apoptosis of CSC cells. |
| Pubmed ID | 28078002 |
| Year | 2016 |
| Title | LncRNA-LINC00152 down-regulated by miR-376c-3p restricts viability and promotes apoptosis of colorectal cancer cells. |
External Links
| Links for LINC00152 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |