Basic Information
| LncRNA/CircRNA Name | LINC00152 |
| Synonyms | CYTOR, C2orf59, LINC00152, NCRNA00152 |
| Region | GRCh38_2:87454781-87636740 |
| Ensemble | ENSG00000222041 |
| Refseq | NR_024204 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Luciferase reporter assay, in vitro knockdown |
| Sample | glioma tissues, cell lines (U87, LN229, U251, and T98G, NHAs) |
| Expression Pattern | up-regulated |
| Function Description | LINC00152 was found to be significantly upregulated in human glioma cell lines and clinical samples.Knockdown of LINC00152 suppressed glioma cell proliferation, migration, and invasion in vitro.LINC00152 knockdown inhibits tumor growth.LINC00152 binds to miR-16 in a sequence-specific manner and suppresses its expression. miR-16 inhibition strongly attenuated LINC00152 knockdown-mediated suppressive effects on proliferation, migration, and invasion.LINC00152 induced BMI1 expression by sponging miR-16,this effect further promoted glioma cell proliferation and invasion.LINC00152 as an oncogenic lncRNA promoting glioma cell proliferation and invasion and as a potential target for human glioma treatment. |
| Pubmed ID | 29669323 |
| Year | 2018 |
| Title | Long Intergenic Noncoding RNA 00152 Promotes Glioma Cell Proliferation and Invasion by Interacting with MiR-16. |
External Links
| Links for LINC00152 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |