Basic Information
| LncRNA/CircRNA Name | LINC00152 |
| Synonyms | CYTOR, C2orf59, LINC00152, NCRNA00152 |
| Region | GRCh38_2:87454781-87636740 |
| Ensemble | ENSG00000222041 |
| Refseq | NR_024204 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gallbladder cancer |
| ICD-0-3 | C23.9 |
| Methods | qPCR, RNAi, Western blot, RIP, Luciferase reporter assay etc. |
| Sample | GBC tissues, cell lines (GBC-SD and H69) |
| Expression Pattern | up-regulated |
| Function Description | LINC00152 is overexpressed in gallbladder cancer (GBC) tissue samples and cell lines.Functionally, LINC00152 dramatically promoted cell migration,invasion and epithelial-mesenchymal transition (EMT) progression in vitro. In vivo, LINC00152 overexpression significantly promoted tumour peritoneal spreading and metastasis. LINC00152 functions as a molecular sponge for miR-138, which directly suppresses the expression of HIF-1a.We revealed that miR-138 is a suppressor of GBC cell metastasis and EMT progression, and a similar phenomenon was observed in HIF-1a knockdown NOZ cells. |
| Pubmed ID | 28077595 |
| Year | 2017 |
| Title | Long non-coding RNA LINC00152 promotes gallbladder cancer metastasis and epithelial-mesenchymal transition by regulating HIF-1a via miR-138. |
External Links
| Links for LINC00152 | GenBank HGNC NONCODE |
| Links for gallbladder cancer | OMIM COSMIC |