Basic Information
| LncRNA/CircRNA Name | ANRIL |
| Synonyms | NA |
| Region | GRCh38_9:21994778-22121097 |
| Ensemble | ENSG00000240498 |
| Refseq | NR_003529 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Propofol | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, etc. |
| Sample | PTC cell line TPC-1 and IHH-4,Normal human thyroid follicular epithelial Nthy-ori 3-1 cell line |
| Expression Pattern | up-regulated |
| Function Description | ANRIL was highly expressed in thyroid cancer, and silence of ANRIL inhibited thyroid cancer cells proliferation, invasion and metastasis. Propofol with a concentration of 6???/mL significantly reduced TPC-1 and IHH-4 cells proliferation and migration, and significantly induced apoptosis. However, 6???/mL of propofol had no significant impacts on the proliferation and apoptosis of normal human thyroid follicular epithelial Nthy-ori 3-1 cells. Meanwhile, the expression of ANRIL in TPC-1 cells was down-regulated by propofol. The anti-tumor activity of propofol was attenuated when ANRIL was overexpressed. Additionally, propofol blocked Wnt/?-catenin and NF-?B pathways in an ANRIL-dependent fashion. |
| Pubmed ID | 30703346 |
| Year | 2019 |
| Title | Propofol suppresses proliferation and migration of papillary thyroid cancer cells by down-regulation of lncRNA ANRIL. |
External Links
| Links for ANRIL | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |