Basic Information
| LncRNA/CircRNA Name | LINC00096 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | Microarray, qRT-PCR, Western blot, Dual Luciferase Reporter Assay |
| Sample | TNBC tissues,TNBC cells (BT-549, MDA-MB-231, MDA-MB-134, MDA-MB-157 and CAL-51) and human breast epithelial cells (MCF-10A) |
| Expression Pattern | up-regulated |
| Function Description | LINC00096 as one of the most upregulated lncRNA in TNBC progression.High LINC00096 expression was obviously related to advanced tumor stage, metastasis, poor prognosis of patients. Loss-of-function assays showed that LINC00096 suppression reduced TNBC cells proliferation and invasive abilities in vitro. Mechanistically, we demonstrated that LINC00096 directly interacted with miR-383-5p, subsequently acted as a miRNA sponge to increase RBM3 expression. |
| Pubmed ID | 31819536 |
| Year | 2019 |
| Title | LINC00096 Promotes the Proliferation and Invasion by Sponging miR-383-5p and Regulating RBM3 Expression in Triple-Negative Breast Cancer |
External Links
| Links for LINC00096 | GenBank HGNC NONCODE |
| Links for triple negative breast cancer | OMIM COSMIC |