Basic Information
| LncRNA/CircRNA Name | LINC00086 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, other |
| Sample | gastric cancer tissues, cell lines (SGC-7901, MKN45, BGC-823, AGS and GES-1) |
| Expression Pattern | down-regulated |
| Function Description | Linc00086 expression was revealed to be downregulated in GC tissues and GC cell lines. Furthermore, it was revealed that 5-aza-dC induced linc00086 expression in SGC-7901 and MKN45 cells, and analysis of CpG methylation by bisulfite sequencing-polymerase chain reaction demonstrated that DNA methylation may regulate the expression of linc00086. MeCP2 is involved in gene regulation by binding to methylated promoters, and it was revealed that the knockdown of the expression of MeCP2 resulted in a higher expression of linc00086. The present study revealed that DNA methylation regulate the expression of linc00086 in human GC cell lines. |
| Pubmed ID | 30008886 |
| Year | 2018 |
| Title | DNA Methylation Contributes to Silencing the Expression of linc00086 in Gastric Cancer |
External Links
| Links for LINC00086 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |