Basic Information
| LncRNA/CircRNA Name | LINC00052 |
| Synonyms | LINC00052, NCRNA00052, TMEM83 |
| Region | GRCh38_15:87576929-87579866 |
| Ensemble | ENSG00000259527 |
| Refseq | NR_026869 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, RNAi, Western blot, Dual luciferase reporter assay etc. |
| Sample | cell line (SMMC7721) |
| Expression Pattern | down-regulated |
| Function Description | We found one LncRNA which called intergenic non-protein coding RNA 52 (LINC00052) has the ability to inhibit invasion and migration of hepatocarcinoma cells. We found that invasion, migration and proliferation abilities in SMMC7721 cell were inhibited after up-expressing LINC00052. We identified that NTRK3 was the target gene of LINC00052. Down-expression of NTRK3 could increase SMMC7721 cell invasion, migration and proliferation. Meanwhile, we discovered that LINC00052 could regulate NTRK3 expression by forming complementary base pairing with miR-128 and miR-485-3p to reduce the luciferase activity of NTRK3 3'UTR. |
| Pubmed ID | 27351280 |
| Year | 2016 |
| Title | LINC00052 regulates the expression of NTRK3 by miR-128 and miR-485-3p to strengthen HCC cells invasion and migration. |
External Links
| Links for LINC00052 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |