Basic Information
| LncRNA/CircRNA Name | LINC00052 |
| Synonyms | LINC00052, NCRNA00052, TMEM83 |
| Region | GRCh38_15:87576929-87579866 |
| Ensemble | ENSG00000259527 |
| Refseq | NR_026869 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | Microarray, qPCR, RNAi, Western blot, ISH etc. |
| Sample | cell lines (BT-549, BT-474, Hs587T, MCF-7, MCF10A, SKBR-3, MDA-MB-231, MDA-MB-468 and HEK293) |
| Expression Pattern | up-regulated |
| Function Description | Gene silencing of LINC00052 diminished both LINC00052 and HER3 expression and reduced cancer cell growth in vitro and in vivo. LINC00052 overexpression promoted cancer cell growth in vitro and in vivo and increased HER3-mediated downstream signaling. Importantly, neutralization of HER3 signaling with HER3 targeting monoclonal antibodies blocked LINC00052 mediated cancer cell proliferation in vitro and tumor growth in vivo, suggesting LINC00052 promoting cancer growth through HER3 signaling. |
| Pubmed ID | 28036286 |
| Year | 2017 |
| Title | HER3 and LINC00052 interplay promotes tumor growth in breast cancer |
External Links
| Links for LINC00052 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |