Basic Information
| LncRNA/CircRNA Name | LIN28B-AS1 |
| Synonyms | C6orf220, LINC00577, dJ439I14.1 |
| Region | GRCh38_6:104864464-104941447 |
| Ensemble | ENSG00000203809 |
| Refseq | NR_046407 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, Microarray, RIP, other |
| Sample | lung cancer tissues and cell lines (NCI-H1299 and A549) |
| Expression Pattern | up-regulated |
| Function Description | It was re-activated in LUAD patients without known genomic alterations in oncogenes and was related to poorer survival. In vitro and In vivo experiments confirmed that the activation of LIN28B could promote the proliferation and metastasis of LUAD cells and can influence cell cycle, DNA damage repair, and genome instability. In addition to the known let-7-LIN28B regulation loop, our results further revealed a let-7-independent Cis-regulator of LIN28B: LIN28B-AS1. LIN28B-AS1 is a CT long non-coding RNA (CT-lncRNA). It altered the messenger RNA stability of LIN28B by directly interacting with another CT protein IGF2BP1 but not with LIN28B and constituted a novel regulation network. |
| Pubmed ID | 30353165 |
| Year | 2019 |
| Title | A Cancer-Testis Non-Coding RNA LIN28B-AS1 Activates Driver Gene LIN28B by Interacting With IGF2BP1 in Lung Adenocarcinoma |
External Links
| Links for LIN28B-AS1 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |