Basic Information
| LncRNA/CircRNA Name | LIMD1-AS1 |
| Synonyms | NA |
| Region | GRCh38_3:45679043-45689134 |
| Ensemble | ENSG00000230530 |
| Refseq | NR_033947 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, RIP etc. |
| Sample | NSCLC tissues, cell lines (A549, H1299, H23,16HBE and SPC-A1) |
| Expression Pattern | down-regulated |
| Function Description | LIMD1 was downregulated in NSCLC samples and cells. Functionally, LIMD1 hindered proliferation and drove apoptosis in NSCLC cells. Moreover, long noncoding RNA (lncRNA) LIMD1 antisense RNA 1 (LIMD1-AS1) was downregulated in NSCLC samples and cell lines. LIMD1-AS1 knockdown abrogated NSCLC cell growth in vitro and in vivo. Mechanistically, LIMD1-AS1 stabilized LIMD1 mRNA through interacting with hnRNP U. Rescue experiments suggested that LIMD1-AS1 repressed NSCLC progression through LIMD1. |
| Pubmed ID | 32239804 |
| Year | 2020 |
| Title | LIMD1-AS1 Suppressed Non-Small Cell Lung Cancer Progression Through Stabilizing LIMD1 mRNA via hnRNP U |
External Links
| Links for LIMD1-AS1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |