Basic Information
| LncRNA/CircRNA Name | LIC01638 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | RT-PCR, Western blotting, ELISA etc. |
| Sample | HPrEC human normal prostate epithelial cell lines, human prostate carcinoma cell lines( 22Rv1 and DU 145), blood samples |
| Expression Pattern | up-regulated |
| Function Description | Plasma levels of LINC01638 lncRNA and Notch1 were upregulated in prostate carcinoma patients comparing with healthy controls. LINC01638 lncRNA and Notch1 were positively correlated in prostate carcinoma patients but not in healthy controls. Upregulation of LINC01638 lncRNA distinguished prostate carcinoma patients from healthy controls. LINC01638 lncRNA overexpression in prostate carcinoma cells led to upregulated Notch1 expression. Notch1 overexpression also led to increased expression level of LINC01638 lncRNA. Both LINC01638 lncRNA and Notch1 overexpression promoted the proliferation, migration and invasion of prostate carcinoma cells. |
| Pubmed ID | 31104008 |
| Year | 2019 |
| Title | LIC01638 lncRNA Promotes the Proliferation, Migration and Invasion of Prostate Carcinoma Cells by Interacting With Notch1 |
External Links
| Links for LIC01638 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |