Basic Information
| LncRNA/CircRNA Name | lncRNA-LET |
| Synonyms | NPTN-IT1, lncRNA-LET |
| Region | GRCh38_15:73567012-73569294 |
| Ensemble | ENSG00000281183 |
| Refseq | NR_103844 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, other |
| Sample | breast cancer tissues and cell lines (MCF-10A, MDA-MB-231) |
| Expression Pattern | down-regulated |
| Function Description | The expression of lncRNA LET was reduced in breast cancer tissues and MDA-MB-231 cells. Overexpression of lncRNA LET resulted in the inhibition of cell proliferation, invasion and migration ability, and promotion of cell apoptosis. Up-regulation of lncRNA LET repressed epithelial mesenchymal transition (EMT) process. |
| Pubmed ID | 30280783 |
| Year | 2018 |
| Title | LncRNA LET Function as a Tumor Suppressor in Breast Cancer Development |
External Links
| Links for lncRNA-LET | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |