Basic Information
| LncRNA/CircRNA Name | LEF-AS1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Luciferase reporter assay, in vitro knockdown etc |
| Sample | CRC tissues, cell lines (HCT116, HT29, SW480, and LoVo) |
| Expression Pattern | up-regulated |
| Function Description | The expression of LEF-AS1 in CRC tissue specimens was found to be markedly higher than that in normal colon tissues. After transfection with LEF-AS1 siRNA, the cell viability, as well as cell migration and invasion capacities, were both attenuated. However, the cell apoptosis rate was conversely elevated. |
| Pubmed ID | 31773695 |
| Year | 2019 |
| Title | LEF-AS1 Participates in Occurrence of Colorectal Cancer Through Adsorbing miR-505 and Promoting KIF3B Expression |
External Links
| Links for LEF-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |