Basic Information
| LncRNA/CircRNA Name | LEF1-AS1 |
| Synonyms | NA |
| Region | GRCh38_4:108167525-108256836 |
| Ensemble | ENSG00000232021 |
| Refseq | NR_029373 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR etc. |
| Sample | ESCC tissues and normal esophageal tissues |
| Expression Pattern | up-regulated |
| Function Description | LEF1-AS1 was distinctly upregulated in ESCC tissues compared with the matched normal tissues .Higher levels of LEF1-AS1 were associated with lymph nodes metastasis and clinical stage. ESCC patients with high LEF1-AS1 level showed a significant shorter 5-year OS and DFS. Multivariate analyses confirmed LEF1-AS1 as an independent prognostic parameter indicating unfavorable clinical prognosis for ESCC patients. |
| Pubmed ID | 31599448 |
| Year | 2019 |
| Title | Upregulation of Long Noncoding RNA LEF1-AS1 Predicts a Poor Prognosis in Patients With Esophageal Squamous Cell Carcinoma |
External Links
| Links for LEF1-AS1 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |