Basic Information
| LncRNA/CircRNA Name | LEF1-AS1 |
| Synonyms | NA |
| Region | GRCh38_4:108167525-108256836 |
| Ensemble | ENSG00000232021 |
| Refseq | NR_029373 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | RT-qPCR, Western blot |
| Sample | HCC tissues,cell lines (HepG2, Hep3B, HuH-7, and SK-HEP-1) |
| Expression Pattern | up-regulated |
| Function Description | HCC tissues and cells contained high lncRNA LEF1-AS1 expression. LncRNA LEF1-AS1 upregulation triggered markedly increased HCC cell proliferation, migration, and invasion and human umbilical vein endothelial cell angiogenesis. |
| Pubmed ID | 32068261 |
| Year | 2020 |
| Title | Silencing of long noncoding RNA LEF1-AS1 prevents the progression of hepatocellular carcinoma via thecrosstalk with microRNA-136-5p/WNK1 |
External Links
| Links for LEF1-AS1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |