Basic Information
| LncRNA/CircRNA Name | LDLRAD4-AS1 |
| Synonyms | NA |
| Region | GRCh38_18:13419421-13427480 |
| Ensemble | ENSG00000267690 |
| Refseq | NR_040031 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR, Western blot |
| Sample | CRC tissues,cell lines |
| Expression Pattern | up-regulated |
| Function Description | LncRNA LDLRAD4-AS1 upregulation enhanced the migration and invasion of CRC cells in vitro and facilitated CRC metastasis in vivo. Mechanistic investigations suggested that lncRNA LDLRAD4-AS1 could decrease the expression of LDLRAD4 by disrupting the stability of LDLRAD4 mRNA, resulting in epithelial-to-mesenchymal transition (EMT) through upregulating Snail,thereby promoting metastasis in CRC. |
| Pubmed ID | 32111819 |
| Year | 2020 |
| Title | Antisense lncRNA LDLRAD4-AS1 promotes metastasis by decreasing the expression of LDLRAD4 and predicts a poor prognosis in colorectal cancer |
External Links
| Links for LDLRAD4-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |