Basic Information
| LncRNA/CircRNA Name | LBX2-AS1 |
| Synonyms | LBX2 antisense RNA 1 |
| Region | GRCh38_2:74502595-74504678 |
| Ensemble | ENSG00000257702 |
| Refseq | NR_024606 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Luciferase reporter assay, RIP, Western blot |
| Sample | GC tissues,gastric mucosa epithelial cell (GES-1) and GC cells (MGC-803, BGC-823, SGC7901, AGS) |
| Expression Pattern | up-regulated |
| Function Description | The up-regulation of LBX2-AS1 in GC tissues and cells was verified. Function assays proved that LBX2-AS1 down-regulation restricted the proliferation ability.LBX2-AS1 positively regulated LBX2 mRNA stability via FUS.LBX2-AS1/miR-219a-2-3p/FUS/LBX2 positive feedback loop mainly affected the proliferation and apoptosis abilities of GC cells. |
| Pubmed ID | 31673844 |
| Year | 2020 |
| Title | LBX2-AS1/miR-219a-2-3p/FUS/LBX2 Positive Feedback Loop Contributes to the Proliferation of Gastric Cancer |
External Links
| Links for LBX2-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |