Basic Information
| LncRNA/CircRNA Name | LBX2-AS1 |
| Synonyms | NA |
| Region | GRCh38_2:74502595-74504678 |
| Ensemble | ENSG00000257702 |
| Refseq | NR_024606 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, Luciferase reporter assay, RIP, Western blot |
| Sample | ESCC tissues,cell line |
| Expression Pattern | up-regulated |
| Function Description | According to the data of TCGA, Ladybird homeobox 2 antisense RNA 1 (LBX2-AS1) is a highly expressed lncRNA in ESCC samples. Herein, we chose it for further study. Furtherly, dysregulation of LBX2-AS1 was identified in ESCC tissues with metastasis. |
| Pubmed ID | 30824187 |
| Year | 2019 |
| Title | LBX2-AS1 is activated by ZEB1 and promotes the development of esophageal squamous cell carcinoma by interacting with HNRNPC to?enhance the stability of ZEB1 and ZEB2 mRNAs. |
External Links
| Links for LBX2-AS1 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |