Basic Information
| LncRNA/CircRNA Name | KTN1-AS1 |
| Synonyms | NA |
| Region | GRCh38_14:55499278-55580110 |
| Ensemble | ENSG00000186615 |
| Refseq | NR_027123 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | head and neck squamous cell carcinoma |
| ICD-0-3 | C76.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay, etc |
| Sample | HNSCC tissues, cell lines (HN4, HN6, HN30, SCC-4, SCC-9, SCC-25, CAL-27, A549 ,HeLa) |
| Expression Pattern | up-regulated |
| Function Description | KTN1-AS1, a competing endogenous RNA, promoted cell proliferation, migration, invasion and epithelial-mesenchymal transition by sponging miR-153-3p in HNSCC. Dysregulation of SNAI1 and ZEB2 mediated the effect of KTN1-AS1 due to miR-153-3p exhaustion. The KTN1-AS1 and miR-153-3p combination can accurately diagnose HNSCC. |
| Pubmed ID | 32267161 |
| Year | 2020 |
| Title | Long Noncoding RNA KTN1-AS1 Promotes Head and Neck Squamous Cell Carcinoma Cell Epithelial-Mesenchymal Transition by Targeting miR-153-3p |
External Links
| Links for KTN1-AS1 | GenBank HGNC NONCODE |
| Links for head and neck squamous cell carcinoma | OMIM COSMIC |