Basic Information
| LncRNA/CircRNA Name | KRTAP5-AS1 |
| Synonyms | NA |
| Region | GRCh38_11:1571353-1599184 |
| Ensemble | ENSG00000233930 |
| Refseq | NR_021489 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Luciferase reporter assay, Western blot, RNA-seq |
| Sample | gastric cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | non-coding RNAs play important roles in the regulatory network of Claudin-4. As such, non-coding RNAs should be considered as potential biomarkers and therapeutic targets against gastric cancer. During the complex process of metastasis, primary cancer cells undergo a sequential series of events including local dissemination, intravasation into the vascular system, survival in the circulatory system, extravasation out of the vascular system,and regrowth at distant sites3,4,5.Among these ncRNAs, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) have appealed to a large group of researchers and become a main focus of attention.Kaplan-Meier analysis of the correlation between CLDN4 expression levels and overall survival. |
| Pubmed ID | 28819095 |
| Year | 2017 |
| Title | Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion. |
External Links
| Links for KRTAP5-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |