Basic Information
LncRNA/CircRNA Name | KRT19P3 |
Synonyms | NA |
Region | NA |
Ensemble | NA |
Refseq | NA |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | apoptosis | Drug | ||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | gastric cancer |
ICD-0-3 | C16 |
Methods | qPCR, Western blot, RNAi, Microarray, Luciferase reporter assays, other |
Sample | gastric cancer tissues and cell lines (SGC7901, MKN45,BGC823, MKN28) |
Expression Pattern | down-regulated |
Function Description | Decreased expression of KRT19P3 was correlated with larger tumor size, advanced TNM stage, Lauren's classification, positive lymph node metastasis, and poor prognosis. Enforced expression of KRT19P3 significantly inhibited cell proliferation, migration, and invasion in vitro, as well as tumorigenesis and metastasis in vivo. Conversely, KRT19P3 knockdown had opposite effects. Mechanistically, RNA pull-down and RNA immunoprecipitation assay revealed that KRT19P3 could directly bind COPS7A. KRT19P3 enhanced COPS7A protein stability in GC cells, and KRT19P3 suppressed GC cell proliferation and metastasis partly through regulation of COPS7A expression. COPS7A could promote deubiquitinylation of I?B?, which was executed by CSN-associated deubiquitinylase USP15, and then KRT19P3 inactivated nuclear factor kappa-B (NF-?B) signaling pathway in a COPS7A-dependent manner. |
Pubmed ID | 31409899 |
Year | 2019 |
Title | Long Non-Coding RNA KRT19P3 Suppresses Proliferation and Metastasis Through COPS7A-mediated NF-?B Pathway in Gastric Cancer |
External Links
Links for KRT19P3 | GenBank HGNC NONCODE |
Links for gastric cancer | OMIM COSMIC |