Basic Information
| LncRNA/CircRNA Name | KIAA0125 |
| Synonyms | FAM30A, C14orf110, HSPC053, KIAA0125 |
| Region | GRCh38_14:105917979-105932642 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gallbladder cancer |
| ICD-0-3 | C23.9 |
| Methods | qPCR etc. |
| Sample | GBC cell lines (GBC-SD, GBC-SD/M) |
| Expression Pattern | up-regulated |
| Function Description | We found the differential expression of a lncRNA, namely, KIAA0125, in a pair of GBC cell sublines which possess different metastatic potentials. Then the effects of KIAA0125 on GBC cell migration, invasion, and epithelial-mesenchymal transitions (EMT) were investigated by using a lentivirus-mediated RNA interference (RNAi) system. Notably, cell migration and invasion were strongly inhibited by KIAA0125 suppression. Moreover, the expression of B-catenin was increased and the expression of Vimentin was decreased in GBC-SD/M cells after KIAA0125 knockdown. |
| Pubmed ID | 26448925 |
| Year | 2015 |
| Title | Long Noncoding RNA KIAA0125 Potentiates Cell Migration and Invasion in Gallbladder Cancer |
External Links
| Links for KIAA0125 | GenBank HGNC NONCODE |
| Links for gallbladder cancer | OMIM COSMIC |