Basic Information
| LncRNA/CircRNA Name | KIAA0125 |
| Synonyms | NA |
| Region | GRCh38_14:105917979-105932642 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot |
| Sample | FHC, HCT116, LS174T, SW480, SW620 and LOVO cell lines, human colorectal carcinoma tissues and adjacent normal colon tissues |
| Expression Pattern | down-regulated |
| Function Description | lncRNA KIAA0125 was down regulated in colorectal tissues and cells. The functional study demonstrated overexpression of KIAA0125 suppressed cell proliferation, migration and invasion whereas the reversal effects were seen in silencing experiment. Besides, KIAA0125 inhibited EMT through Wnt/?-catenin signaling in CRC. |
| Pubmed ID | 31228314 |
| Year | 2019 |
| Title | LncRNA KIAA0125 functions as a tumor suppressor modulating growth and metastasis of colorectal cancer via Wnt/?-catenin pathway |
External Links
| Links for KIAA0125 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |