Basic Information
| LncRNA/CircRNA Name | KCNQ1OT1 |
| Synonyms | KCNQ1OT1, KCNQ1-AS2, KCNQ10T1, Kncq1, KvDMR1, KvLQT1-AS, LIT1, NCRNA00012 |
| Region | GRCh38_11:2608328-2699994 |
| Ensemble | ENSG00000269821 |
| Refseq | NR_002728 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qPCR |
| Sample | peripheral blood |
| Expression Pattern | up-regulated |
| Function Description | The expression of LncRNA KCNQ1OT1 was associated with NCCN risk grade and survival status in patients with AML. The median overall survival time was significantly shorter in patients with high expression of LncRNA KCNQ1OT1 than that in patients with low expression(P<0.05). |
| Pubmed ID | 29950199 |
| Year | 2018 |
| Title | [Expression and Clinical Significance of LncRNA KCNQ1OT1 in Patients with Acute Myeloid Leukemia]. |
External Links
| Links for KCNQ1OT1 | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |