Basic Information
| LncRNA/CircRNA Name | KCNQ1OT1 |
| Synonyms | KCNQ1OT1, KCNQ1-AS2, KCNQ10T1, Kncq1, KvDMR1, KvLQT1-AS, LIT1, NCRNA00012 |
| Region | GRCh38_11:2608328-2699994 |
| Ensemble | ENSG00000269821 |
| Refseq | NR_002728 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, RIP, Luciferase reporter assay |
| Sample | brain tumor tissues, cell lines (U87, U251) |
| Expression Pattern | up-regulated |
| Function Description | KCNQ1OT1 expression was up-regulated in glioma tissues and cells.These results provided a comprehensive analysis of KCNQ1OT1-miR-370-CCNE2 axis in human glioma cells and might provide a novel strategy for glioma treatment. |
| Pubmed ID | 28381990 |
| Year | 2017 |
| Title | Knockdown of Long Non-Coding RNA KCNQ1OT1 Restrained Glioma Cells??Malignancy by Activating miR-370/CCNE2 Axis |
External Links
| Links for KCNQ1OT1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |