Basic Information
| LncRNA/CircRNA Name | KCNQ1OT1 |
| Synonyms | NA |
| Region | GRCh38_11:2608328-2699994 |
| Ensemble | ENSG00000269821 |
| Refseq | NR_002728 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy/apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | tumor and adjacent normal tissues ,human colon cancer cell lines(HCT116 and SW480) |
| Expression Pattern | up-regulated |
| Function Description | The expression level of KCNQ1OT1 was increased in tumor, which indicated poor prognosis in colon cancer patients.Knockdown of KCNQ1OT1 decreased the cell viability and increased the apoptosis rates upon L-OHP treatment.Atg4B upregulation was partially responsible for KCNQ1OT1-induced protective autophagy and chemoresistance.Moreover, miR-34a functioned as a bridge between KCNQ1OT1 and Atg4B, which could be sponged by KCNQ1OT1, while it could also bind to the 3'-UTR of Atg4B and downregulate its expressions.KCNQ1OT1/miR-34a/Atg4B axis regulated the chemoresistance of colon cancer cells in vitro and in vivo. |
| Pubmed ID | 31040703 |
| Year | 2019 |
| Title | lncRNA KCNQ1OT1 Enhances the Chemoresistance of Oxaliplatin in Colon Cancer by Targeting the miR-34a/ATG4B Pathway |
External Links
| Links for KCNQ1OT1 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |