Basic Information
| LncRNA/CircRNA Name | KCNQ1OT1 |
| Synonyms | NA |
| Region | GRCh38_11:2608328-2699994 |
| Ensemble | ENSG00000269821 |
| Refseq | NR_002728 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, RIP, Luciferase reporter assay |
| Sample | cell lines (MG63,Saos-2,hFOB1.19) |
| Expression Pattern | up-regulated |
| Function Description | Here, we report that lncRNA KCNQ1OT1 was upregulated in OS. Meanwhile, functional experiments demonstrated that the KCNQ1OT1 facilitated proliferation and suppressed apoptosis of OS cells. KCNQ1OT1 contributed to the Warburg effect by stimulating aldolase A (ALDOA) expression. |
| Pubmed ID | 32332718 |
| Year | 2020 |
| Title | LncRNA KCNQ1OT1 sponges miR-34c-5p to promote osteosarcoma growth via ALDOA enhanced aerobic glycolysis. |
External Links
| Links for KCNQ1OT1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |