Basic Information
| LncRNA/CircRNA Name | KCNQ1OT1 |
| Synonyms | NA |
| Region | GRCh38_11:2608328-2699994 |
| Ensemble | ENSG00000269821 |
| Refseq | NR_002728 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Oxaliplatin | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | hepatocellular carcinoma tissues, cell lines (SMMC-7721, Huh7, SK-Hep-1 and HepG2) |
| Expression Pattern | up-regulated |
| Function Description | Results showed that KCNQ1OT1 was significantly up-regulated in oxaliplatin-resistant HepG2 and Huh7 cells. Moreover, knockdown of KCNQ1OT1 inhibited the cell proliferation, migration, invasion and reduced the expression of drug-resistant gene (MRP5, MDR1, LRP1). Additionally, bioinformatics analysis and dual-luciferase reporter assay showed that miR-7-5p directly targeted the 3'-UTR of miR-7-5p and ABCC1 mRNA, indicating that KCNQ1OT1 regulated the expression of ABCC1 via endogenous sponging miR-7-5p. |
| Pubmed ID | 29966655 |
| Year | 2018 |
| Title | Long Non-Coding RNA KCNQ1OT1 Modulates Oxaliplatin Resistance in Hepatocellular Carcinoma Through miR-7-5p/ ABCC1 Axis |
External Links
| Links for KCNQ1OT1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |