Basic Information
| LncRNA/CircRNA Name | KCNQ1OT1 |
| Synonyms | NA |
| Region | GRCh38_11:2608328-2699994 |
| Ensemble | ENSG00000269821 |
| Refseq | NR_002728 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | maxillary sinus squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | RT-qPCR, Western blot |
| Sample | MSSCC tissues,MSSCC cell line |
| Expression Pattern | up-regulated |
| Function Description | KCNQ1OT1 expression was markedly upregulated in MSSCC tissues and MSSCC cell line (IMC-3) by using quantitative reverse transcription-polymerase chain reaction. Loss-of-function experiments revealed that the deletion of KCNQ1OT1 inhibited cell proliferation, migration, and invasion. |
| Pubmed ID | 31709597 |
| Year | 2019 |
| Title | Long noncoding RNA KCNQ1OT1 promotes proliferation, migration, and invasion in maxillary sinus squamous cell carcinoma by regulating miR-204/EphA7 axis |
External Links
| Links for KCNQ1OT1 | GenBank HGNC NONCODE |
| Links for maxillary sinus squamous cell carcinoma | OMIM COSMIC |