Basic Information
| LncRNA/CircRNA Name | KCNQ1DN |
| Synonyms | KCNQ1DN, BWRT, HSA404617 |
| Region | GRCh38_11:2870033-2872105 |
| Ensemble | ENSG00000237941 |
| Refseq | NR_024627 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | wilms tumor |
| ICD-0-3 | C64.9 |
| Methods | qPCR etc. |
| Sample | Wilms tumor tissues |
| Expression Pattern | down-regulated |
| Function Description | We examined the expression of KCNQ1DN in Wilms' tumors. Seven of eighteen (39%) samples showed no expression. In contrast, other maternal imprinted genes in this region, including p57(KIP2), IMPT1, and IPL exhibited almost normal expression in these samples, although some samples expressed IGF2 biallelically. These results suggest that KCNQ1DN existing far from the H19/IGF2 region may play some role in Wilms' tumorigenesis along with IGF2. |
| Pubmed ID | 11056398 |
| Year | 2000 |
| Title | A novel imprinted gene, KCNQ1DN, within the WT2 critical region of human chromosome 11p15.5 and its reduced expression in Wilms' tumors. |
External Links
| Links for KCNQ1DN | GenBank HGNC NONCODE |
| Links for wilms tumor | OMIM COSMIC |